# HALOWERK biowerk > HALOWERK biowerk provides machine-readable results paid via x402. > Netz Base Mainnet, Zahlungsmittel USDC, Empfänger 0x2880EdfFF13100677Bf97A3CBdF3Bc34771C4E5E. ## So wird bezahlt 1. Call the route without a payment header. The 402 response includes accepts, description, and inputSchema. 2. Bedingungen mit einem x402-Client signieren. 3. Repeat the call with the proof in the PAYMENT-SIGNATURE header. Eine 402-Antwort kostet nichts und löst keine Arbeit aus. Scheitert die Arbeit, trägt die Antwort charged=false und es wird nicht abgerechnet. ## Endpunkte ### POST /v1/protein-folding Checks that a hydrophobic/polar sequence follows a self-avoiding unit-step lattice path, then counts non-consecutive hydrophobic contacts and assigns one negative energy unit per contact. It evaluates a supplied toy conformation only; it neither predicts a fold nor represents atomic chemistry, kinetics, solvent or biological function. - Preis: 0.004 USDC - MCP-Werkzeug: `biowerk_protein_folding` - Eingabe: `["hp_sequence","coordinates"]` ### POST /v1/crispr-offtarget Compares one guide with caller-supplied candidate protospacers, weights mismatches in the guide’s final ten positions twice, applies a simple NGG PAM penalty, and ranks a transparent similarity score. It does not search a genome, model bulges, chromatin or nuclease-specific biology, and must not be used as a clinical or laboratory safety decision. - Preis: 0.004 USDC - MCP-Werkzeug: `biowerk_crispr_offtarget` - Eingabe: `["guide","candidates"]` ### POST /v1/dna-storage-encode Maps each two-bit group of caller-supplied UTF-8 bytes to A, C, G or T and reports a SHA-256 checksum of the original bytes. This reversible representation performs no biological synthesis, homopolymer balancing, GC optimization, addressing or error-correcting code. - Preis: 0.003 USDC - MCP-Werkzeug: `biowerk_dna_storage_encode` - Eingabe: `["text"]` ### POST /v1/microbiome-diversity Normalizes non-negative caller-supplied taxon counts and computes observed richness, natural-log Shannon entropy, Simpson diversity and Pielou evenness. It does not perform sequence classification, compositional correction, rarefaction, cohort comparison or medical interpretation. - Preis: 0.003 USDC - MCP-Werkzeug: `biowerk_microbiome_diversity` - Eingabe: `["taxa"]` ### POST /v1/pathogen-r0 Multiplies per-contact transmission probability, effective contacts per day and infectious duration to obtain a simple basic reproduction number, then applies a susceptible fraction for an effective number. It is a classroom homogeneous-mixing calculation, not an outbreak estimate, fitted epidemiological model or public-health forecast. - Preis: 0.003 USDC - MCP-Werkzeug: `biowerk_pathogen_r0` - Eingabe: `["transmission_probability_per_contact","effective_contacts_per_day","infectious_duration_days","susceptible_fraction"]` ### POST /v1/biomarker-longevity Standardizes each supplied value against its supplied mean and standard deviation, flips markers whose favorable direction is lower, and computes a weighted composite mapped to a bounded 0–100 index. The references and weights come entirely from the caller; this is not a validated longevity score, diagnosis, prognosis or medical advice. - Preis: 0.003 USDC - MCP-Werkzeug: `biowerk_biomarker_longevity` - Eingabe: `["biomarkers"]` ### POST /v1/syn-yeast-yield Divides each available substrate mass by its required mass per product mass, selects the limiting substrate, and applies a caller-supplied process efficiency. It does not model yeast metabolism, kinetics, oxygen transfer, toxicity, regulation or actual fermentation performance. - Preis: 0.003 USDC - MCP-Werkzeug: `biowerk_syn_yeast_yield` - Eingabe: `["substrates","process_efficiency"]` ### POST /v1/allergen-epitope Builds amino-acid k-mer sets, calculates Jaccard similarity, and finds the highest contiguous identity between each supplied epitope and any equal-length window of the query. It does not predict immune binding, allergenicity, cross-reactivity or clinical risk and cannot replace curated databases or laboratory testing. - Preis: 0.004 USDC - MCP-Werkzeug: `biowerk_allergen_epitope` - Eingabe: `["query_sequence","known_epitopes","kmer_size"]` ### POST /v1/phage-matching Slides each caller-supplied spacer over a bounded phage sequence in both orientations, records its minimum Hamming distance and reports matches within a caller-selected mismatch threshold. It does not account for PAMs, phage taxonomy, infection biology, escape, host range or therapeutic suitability. - Preis: 0.004 USDC - MCP-Werkzeug: `biowerk_phage_matching` - Eingabe: `["phage_sequence","spacers","max_mismatches"]` ### POST /v1/tissue-scaffold Uses the Kozeny-Carman relation with supplied porosity and pore diameter, then applies Darcy’s law with supplied thickness, viscosity and pressure drop. It is an idealized homogeneous porous-medium calculation, not scaffold design validation, cell-transport modeling, biocompatibility assessment or medical guidance. - Preis: 0.003 USDC - MCP-Werkzeug: `biowerk_tissue_scaffold` - Eingabe: `["porosity_fraction","mean_pore_diameter_um","scaffold_thickness_mm","fluid_dynamic_viscosity_pa_s","pressure_drop_pa","kozeny_constant"]` ## Weitere Flächen - OpenAPI: https://bio.halowerk.com/openapi.json - Preise: https://bio.halowerk.com/pricing - x402-Manifest: https://bio.halowerk.com/.well-known/x402 - Bazaar: https://bio.halowerk.com/.well-known/x402/bazaar - MCP: https://bio.halowerk.com/mcp ## Missing a capability? If you looked for something this service does not offer, say so. One call, no payment, no sign-up, no account: POST https://bedarf.halowerk.com/capabilities/request Content-Type: application/json {"requested_capability": "what you would buy", "description": "the use case, one sentence", "callback_url": "optional - we call back once it exists"} Only requested_capability is required, 3 to 160 characters. Schema and status: https://bedarf.halowerk.com/openapi.json Submissions are held for review and are never published verbatim.